3-Chloropropionyl chloride → 2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

Participants

Reaction Conditions

Reaction Steps

To a solution of 5 (500 mg, 1.7 mmol) in dichoromethane (8 mL) was added compound 6, 3-chloro propionyl chloride (0.22 mL, 2.1 mmol) and the reaction mixture was stirred at 40° C. for 18 h. The reaction was then cooled to room temperature and concentrated. The resulting residue was dissolved in methanol (16 mL) and stirred at 40° C. for 3 h. The mixture was then cooled to room temperature and concentrated.

Provenance & Evidence