1-Amino-3-(4-chloro-phenyl)-propan-2-one hydrochloride → 3-benzyloxy-7-morpholin-4-yl-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylic acid [3-(4-chloro-phenyl)-2-oxo-propyl]-amide

HRID 1043829Notes

Reaction equation

HRID 1043829 reaction equation
[CH2:1]([O:8][C:9]1[C:14](=[O:15])[N:13]2[CH:16]=[C:17]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[CH:18]=[CH:19][C:12]2=[N:11][C:10]=1[C:26](O)=[O:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:30][CH2:31][C:32](=[O:41])[CH2:33][C:34]1[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][CH:35]=1>>[Cl:40][C:37]1[CH:36]=[CH:35][C:34]([CH2:33][C:32](=[O:41])[CH2:31][NH:30][C:26]([C:10]2[N:11]=[C:12]3[CH:19]=[CH:18][C:17]([N:20]4[CH2:21][CH2:22][O:23][CH2:24][CH2:25]4)=[CH:16][N:13]3[C:14](=[O:15])[C:9]=2[O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[O:27])=[CH:39][CH:38]=1

Participants

3

Reactant 2

HCID 132906761-Amino-3-(4-chloro-phenyl)-propan-2-one hydrochlorideHCID 574945733-benzyloxy-7-morpholin-4-yl-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylic acid

Product 1

HCID 669532693-benzyloxy-7-morpholin-4-yl-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylic acid [3-(4-chloro-phenyl)-2-oxo-propyl]-amide

Procedure

Adapted the procedure of example 2 using 3-benzyloxy-7-morpholin-4-yl-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylic acid and 1-amino-3-(4-chloro-phenyl)-propan-2-one hydrochloride (AU2007001980) as starting material

Sources & evidence

ORD record
ord-8d2ea4fe0f094cecbf0b22129a415c00
Source dataset
uspto-grants-2013_10
Patent number
US08563562B2

Reaction notes

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