Benzyl carbazate → HCID 86686317, compound

HRID 1043874Notes

Reaction equation

HRID 1043874 reaction equation
O=[C:2]1[CH2:6][CH2:5][O:4][CH2:3]1.[C:7]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=[O:10])[NH:8][NH2:9]>CO>[O:4]1[CH2:5][CH2:6][C:2](=[N:9][NH:8][C:7]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[CH2:3]1

Participants

4

Reactant 2

HCID 79242Benzyl carbazateHCID 5293923-Oxotetrahydrofuran

Product 1

HCID 86686317HCID 86686317, compoundYield 105%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-oxotetrahydrofuran (5.70 g) was dissolved in methanol (150 mL), and benzyl carbazate (10 g) was added to the solution. The mixture was stirred at room temperature for 12 hours. The reaction mixture was concentrated. 14.8 g of a residue was obtained as a crude purified product. This was used for the next reaction without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-e242cff8b09b44d8a1ea590a3b03d261
Source dataset
uspto-grants-2013_10
Patent number
US08563565B2

Reaction notes

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