反应详情

温度

60 °C

3-bromo-6-chloro-2,4-dimethylpyridine obtained in Preparation Example 21 (200 mg) was added to DMF (1 mL). Sodium methoxide (28% solution in methanol, 0.741 mL) was added to the solution, and the mixture was stirred at 60° C. for 15 hours. Water was added to the reaction mixture, followed by extraction with diethyl ether. The organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 10%) to give the title compound (172 mg).

1. extractionfollowed by extraction with diethyl ether
2. concentrationThe organic layer was concentrated under reduced pressure
3. customThe residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 10%)