反应详情

A mixture of 3-bromo-2-chloro-4,6-dimethylpyridine (2.97 g) and sodium methoxide (11.0 mL, 28% solution in methanol) was stirred in a DMF solvent (30 mL) at 80° C. for 36 hours. Water was added to the reaction mixture, followed by extraction with diethyl ether. The organic layer was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 10%) to give the title compound (2.33 g).

1. extractionfollowed by extraction with diethyl ether
2. concentrationThe organic layer was concentrated under reduced pressure
3. customthe residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 10%)