反应详情

A solution of 6-[(2,2-diphenylethyl)amino]-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2-carbonitrile (Preparation 5) (17 g, 40.1 mmol) in ethanol (850 ml) was treated with 2 N aqueous hydrochloric acid (50 ml) and the mixture stirred at room temperature for 24 hours. The solvent was removed under reduced pressure, the residue dissolved in ethanol and the solvent again removed under reduced pressure. The residue was triturated with diethyl ether, filtered, washed with diethyl ether and pentane, and dried to afford the title compound as a solid (13,6 g).

1. customThe solvent was removed under reduced pressure
2. dissolutionthe residue dissolved in ethanol
3. customthe solvent again removed under reduced pressure
4. customThe residue was triturated with diethyl ether
5. filtrationfiltered
6. washwashed with diethyl ether and pentane
7. customdried