反应详情

温度

100 °C

2-chloro-4,6-dimethylpyridine (CAS number: 30838-93-8) (400 mg) was added to DMF (3.3 mL). Sodium methoxide (28% solution in methanol, 2.6 mL) was added to the solution, and the mixture was stirred at 100° C. for 12 hours. The reaction mixture was partitioned by adding ethyl acetate and water. The organic layer was dried over anhydrous magnesium sulfate. The desiccant was removed by filtration. The filtrate was concentrated under reduced pressure to give the title compound (380 mg) as a 50% solution in DMF.

1. customThe reaction mixture was partitioned
2. additionby adding ethyl acetate and water
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. customThe desiccant was removed by filtration
5. concentrationThe filtrate was concentrated under reduced pressure