Hydrogen Bromide → 5-Amino-4,6-dibromopyridine-2-carbonitrile

Participants

Reaction Steps

5-amino-2-cyanopyridine (2 g) was added to a 48% aqueous hydrogen bromide solution (14 mL). Bromine (2.2 mL) was added to the solution at 0° C. The reaction mixture was warmed to room temperature and stirred for six hours. The precipitated solid was collected by filtration to give the title compound (4.5 g).

Provenance & Evidence