Hydrogen Bromide → 5-Amino-4,6-dibromopyridine-2-carbonitrile

HRID 1043920Notes

Reaction equation

HRID 1043920 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[N:9])=[N:6][CH:7]=1.[BrH:10].[Br:11]Br>>[NH2:1][C:2]1[C:3]([Br:11])=[CH:4][C:5]([C:8]#[N:9])=[N:6][C:7]=1[Br:10]

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 38713955-Aminopyridine-2-carbonitrile

Product 1

HCID 866863455-Amino-4,6-dibromopyridine-2-carbonitrile

Procedure

5-amino-2-cyanopyridine (2 g) was added to a 48% aqueous hydrogen bromide solution (14 mL). Bromine (2.2 mL) was added to the solution at 0° C. The reaction mixture was warmed to room temperature and stirred for six hours. The precipitated solid was collected by filtration to give the title compound (4.5 g).

Workup

  1. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-83bbe35355414395b70b91288e7f122c
Source dataset
uspto-grants-2013_10
Patent number
US08563565B2

Reaction notes

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