Iodoethane → HCID 86686354, compound

HRID 1043931Notes

Reaction equation

HRID 1043931 reaction equation
[Br:1][C:2]1[C:3]([CH3:10])=[CH:4][C:5]([OH:9])=[N:6][C:7]=1[CH3:8].[CH2:11](I)[CH3:12]>C(Cl)(Cl)Cl.C(=O)([O-])[O-].[Ag+2]>[Br:1][C:2]1[C:7]([CH3:8])=[N:6][C:5]([O:9][CH2:11][CH3:12])=[CH:4][C:3]=1[CH3:10]

Participants

5

Reactant 2

HCID 6340IodoethaneHCID 178429301HCID 178429301, compound

Product 1

HCID 86686354HCID 86686354, compound

Reagents, catalysts & solvents 2

HCID 178418647HCID 178418647, compoundCatalystHCID 6212ChloroformSolvent

Procedure

A mixture of 5-bromo-4,6-dimethylpyridin-2-ol obtained in Preparation Example 23(1) (50 mg), ethyl iodide (2.0 mL) and silver carbonate (1.4 g) was stirred in a chloroform solvent (10 mL) at room temperature for 36 hours. The reaction mixture was subjected to silica gel pad and eluted with a mixed solvent of (ethyl acetate/n-heptane, 10%). The resulting solution was concentrated under reduced pressure to give the title compound (550 mg).

Workup

  1. washeluted with a mixed solvent of (ethyl acetate/n-heptane, 10%)
  2. concentrationThe resulting solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-51e253fad2a34b419fef113e179e1164
Source dataset
uspto-grants-2013_10
Patent number
US08563565B2

Reaction notes

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