反应详情

温度

100 °C

4-Fluoro-N-methylaniline (0.33 g, 2.67 mmol) was added to a solution of ethyl 2-bromo-2-phenylacetate (0.36 ml, 2.06 mmol) in acetonitrile (6.86 ml) and DIPEA (0.47 ml, 2.67 mmol). The dark solution was stirred at 100° C. under microwave irradiation for 1 hour. Then solvent was evaporated and the crude was purified by flash chromatography (Petroleum ether/EtOAc=97/3) to obtain intermediate I5 (0.59 g, 100% yield).

1. customThen solvent was evaporated
2. customthe crude was purified by flash chromatography (Petroleum ether/EtOAc=97/3)
3. customto obtain intermediate I5 (0.59 g, 100% yield)