HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → Methyl 2-(3-fluorophenyl)-2-(phenylamino)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methyl 2-bromo-2-(3-fluorophenyl)acetate | HCID 57495616 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Methyl 2-(3-fluorophenyl)-2-(phenylamino)acetate | HCID 54889725 | 73% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
Methyl 2-bromo-2-(3-fluorophenyl)acetate (I15) (300 mg, 1.21 mmol), DIPEA (0.32 ml, 1.82 mmol), and aniline (0.17 ml, 1.82 mmol) were dissolved in acetonitrile (4 ml) and heated under microwave irradiation at 100° C. for 1 hour. Acetonitrile was evaporated, and the residue was purified by flash chromatography (Petroleum ether/EtOAc=95/5) to obtain intermediate I16 (229 mg, 73% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563577B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-414547ee2ea84c88a5c5cd6c97006ea9 |
| Source note | uspto-grants-2013_10 |