反应详情

温度

100 °C

Methyl 2-bromo-2-(3-fluorophenyl)acetate (I15) (300 mg, 1.21 mmol), DIPEA (0.32 ml, 1.82 mmol), and aniline (0.17 ml, 1.82 mmol) were dissolved in acetonitrile (4 ml) and heated under microwave irradiation at 100° C. for 1 hour. Acetonitrile was evaporated, and the residue was purified by flash chromatography (Petroleum ether/EtOAc=95/5) to obtain intermediate I16 (229 mg, 73% yield).

1. customAcetonitrile was evaporated
2. customthe residue was purified by flash chromatography (Petroleum ether/EtOAc=95/5)
3. customto obtain intermediate I16 (229 mg, 73% yield)