反应详情

温度

100 °C

2,5-Difluoroaniline (0.19 ml, 1.85 mmol), ethyl 2-bromo-2-phenylacetate (0.22 ml, 1.23 mmol), and DIPEA (0.32 ml, 1.85 mmol) were dissolved in acetonitrile (3 ml) and heated under MW irradiation at 100° C. for 6 hours and then at 110° C. for 4 hours. Acetonitrile was evaporated, and the crude product was purified by flash chromatography (Petroleum ether/EtOAc=97/3) to obtain intermediate I19 (240 mg, 67% yield).

1. customAcetonitrile was evaporated
2. customthe crude product was purified by flash chromatography (Petroleum ether/EtOAc=97/3)
3. customto obtain intermediate I19 (240 mg, 67% yield)