反应详情

Thiophene-2-carboxamide (0.8 g, 6.29 mmol) and 1,3-dichloropropan-2-one (0.96 g, 7.55 mmol) were heated at 150° C. for 2.5 hours. The dark solid was dissolved in EtOAc and washed with aqueous NaHCO3, then the organic phase was dried over Na2SO4, filtered and evaporated to dryness. The dark brown oil was purified by flash chromatography (Petroleum ether/EtOAc=9/1) to obtain 4-(chloromethyl)-2-(thiophen-2-yl)oxazole (790 mg, 63% yield).

1. washwashed with aqueous NaHCO3
2. dry with materialthe organic phase was dried over Na2SO4
3. filtrationfiltered
4. customevaporated to dryness
5. customThe dark brown oil was purified by flash chromatography (Petroleum ether/EtOAc=9/1)