Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | HCID 58577374 | HCID 58577374 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 58577725 | HCID 58577725 | — |
Reaction Steps
To a solution of 2-{[4-(benzyloxy)phenyl]amino}-4-(trifluoromethyl)pyridine-3-carboxylic acid (221 mg) and Et3N (0.238 mL) in toluene (15 mL) was added diphenylphosphoryl azide (0.245 mL) at room temperature. The mixture was stirred at 110° C. for 4 h. After cooling, the solvent was evaporated, and the precipitate was collected by filtration to give the title compound (197 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08563575B2 |
|---|
| Source dataset | uspto-grants-2013_10 |
|---|
| ORD ID | ord-e1f31bdc83884a50bc4d07d04875642d |
|---|
| Source note | uspto-grants-2013_10 |
|---|
