Methanol → HCID 178525737, compound

HRID 1044383Notes

Reaction equation

HRID 1044383 reaction equation
[C:1]([O:9][C@@H:10]1[CH2:15][CH2:14][C@H:13]([N:16]2[CH2:20][CH2:19][C@:18]3([CH2:25][CH2:24][CH2:23][N:22](C(OCC4C=CC=CC=4)=O)[CH2:21]3)[C:17]2=[O:36])[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO>[Pd]>[C:1]([O:9][C@H:10]1[CH2:15][CH2:14][C@@H:13]([N:16]2[CH2:20][CH2:19][C@:18]3([CH2:25][CH2:24][CH2:23][NH:22][CH2:21]3)[C:17]2=[O:36])[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 178525738HCID 178525738, compound

Product 1

HCID 178525737HCID 178525737, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Benzyl (5S)-2-[cis-4-(benzoyloxy)cyclohexyl]-1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate (0.16 g, 0.00033 mol) in methanol (5 mL, 0.1 mol) was stirred with palladium (20 mg, 0.00002 mol) under an atmosphere of hydrogen for 2 h. The mixture was filtered and the filtrate was concentrated to afford the desired product. LC-MS: 357.2 (M+H)+.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-7d20c5566f2c4258bdea1dd075b3b822
Source dataset
uspto-grants-2013_10
Patent number
US08563570B2

Reaction notes

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