Methanol → HCID 46910989, compound

HRID 1044400Notes

Reaction equation

HRID 1044400 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][C:10]2[CH:15]=[CH:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23]OCC[Si](C)(C)C)=[C:18]([O:31][CH3:32])[CH:17]=3)[C:12](=[O:33])[CH:11]=2)=[CH:4][CH:3]=1.[CH3:34]O.Cl.[O:37]1[CH2:42][CH2:41]OCC1>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][C:10]2[CH:15]=[CH:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][C:42]([OH:37])([CH3:34])[CH3:41])=[C:18]([O:31][CH3:32])[CH:17]=3)[C:12](=[O:33])[CH:11]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 204431481,4-Dioxane hydrochlorideHCID 58580200HCID 58580200, compound

Product 1

HCID 46910989HCID 46910989, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-((4-fluorophenylthio)methyl)-1-(3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)phenyl)pyridin-2(1H)-one Part A (64 mg, 0.13 mmol) in CH2Cl2 (1.0 mL) and MeOH (1.0 mL) was added 4M HCl/Dioxane (2 mL, 8M mmol). After stirring at RT for 2 h, concentration under vacuum provided the crude phenol as a white solid. LC-MS, [M+H]+=358.

Workup

  1. concentrationconcentration under vacuum

Sources & evidence

ORD record
ord-3e93bdc9b3f6421a936cb3cf88a9b1dc
Source dataset
uspto-grants-2013_10
Patent number
US08563583B2

Reaction notes

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