反应详情

A mixture of 4-(benzyloxy)-1-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyridin-2(1H)-one Part B (287 mg, 0.73 mmol) and 10% Pd/C (7.72 mg, 0.073 mmol) in MeOH (15 mL) was hydrogenated at 50 PSI of H2 for 4 hours. Pd/C was filtered off and the filtrate was concentrated giving 4-hydroxy-1-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyridin-2(1H)-one 7C (228 mg, 98% yield).

1. filtrationPd/C was filtered off
2. concentrationthe filtrate was concentrated