HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(benzyloxy)-1-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyridin-2(1H)-one → 4-hydroxy-1-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(benzyloxy)-1-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyridin-2(1H)-one | HCID 58580264 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-hydroxy-1-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyridin-2(1H)-one | HCID 58580293 | 98% |
Reaction Steps
A mixture of 4-(benzyloxy)-1-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyridin-2(1H)-one Part B (287 mg, 0.73 mmol) and 10% Pd/C (7.72 mg, 0.073 mmol) in MeOH (15 mL) was hydrogenated at 50 PSI of H2 for 4 hours. Pd/C was filtered off and the filtrate was concentrated giving 4-hydroxy-1-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyridin-2(1H)-one 7C (228 mg, 98% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563583B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-7c1a325aab9b4796a11d545cc0f8728a |
| Source note | uspto-grants-2013_10 |