反应详情

温度

87.5 °C

1-methyl-4-piperidone (340 g, 3.0 mol) was added slowly, to a solution of 1,3,5-trimethoxybenzene (500 g, 2.97 mol) in glacial acetic acid (600 mL), maintaining the temperature of the reaction mixture below 40° C. Conc. HCl (450 mL) was added over 20 min. The temperature was raised to 85-90° C. and the reaction mixture was stirred for 3.5 h. It was allowed to cool to 40° C., poured over crushed ice (4 kg) and stirred for 20 min. The precipitate of unreacted 1,3,5-trimethoxybenzene was filtered off. The filtrate was basified, below 10° C., to pH 11-12 using a 50% aqueous NaOH solution. The off white solid obtained was filtered, washed with water and dried to obtain the compound, 1-methyl-4-(2,4,6-trimethoxy-phenyl)-1,2,3,6-tetrahydropyridine.

1. temperaturemaintaining the temperature of the reaction mixture below 40° C
2. temperatureto cool to 40° C.
3. additionpoured
4. stirringstirred for 20 min
5. filtrationThe precipitate of unreacted 1,3,5-trimethoxybenzene was filtered off
6. customwas basified, below 10° C., to pH 11-12
7. customThe off white solid obtained
8. filtrationwas filtered
9. washwashed with water
10. customdried