Acetyl chloride → HCID 57467309, compound

HRID 1044516Notes

Reaction equation

HRID 1044516 reaction equation
F[C:2](F)(F)[C:3]([OH:5])=O.[NH2:8][CH:9]1[CH:18]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:17]2[CH:16]=[C:15]([CH2:26][NH:27][S:28]([CH2:31][CH2:32][CH3:33])(=[O:30])=[O:29])[CH:14]=[CH:13][C:12]=2[CH2:11][CH2:10]1.C(Cl)(=O)C.C(N(C(C)C)C(C)C)C>ClCCl>[CH2:19]([CH:18]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([CH2:26][NH:27][S:28]([CH2:31][CH2:32][CH3:33])(=[O:30])=[O:29])[CH:16]=2)[CH2:11][CH2:10][CH:9]1[NH:8][C:3](=[O:5])[CH3:2])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 81531DiisopropylethylamineHCID 68513876HCID 68513876, compound

Product 1

HCID 57467309HCID 57467309, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide (cf. example 42) was acetylated in dichloromethane with acetyl chloride in the presence of ethyldiisopropylamine at room temperature.

Sources & evidence

ORD record
ord-37e53ce085844183a43cd18ec261b5cf
Source dataset
uspto-grants-2013_10
Patent number
US08563617B2

Reaction notes

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