反应详情

A mixture of propane-1-sulfonic acid cyclopropyl amide (1.3 g, 8 mmol), K2CO3 (2.4 g, 14.4 mmol) and acetic acid 2-bromo-ethyl ester (9.5 g, 16 mmol) mmol) in 10 ml acetone was heated for 6 h to 120° C. in the microwave (Biotage). After cooling the mixture was filtered and the solvent evaporated to obtain 1.7 g of product as an oil which was used without further purification in the next step.

1. temperaturewas heated for 6 h to 120° C. in the microwave (Biotage)
2. temperatureAfter cooling the mixture
3. filtrationwas filtered
4. customthe solvent evaporated