反应详情

To a solution of propane-1-sulfonic acid cyclopropyl-(2-hydroxy-ethyl)-amide (150 mg, 0.8 mmol) in CH2Cl2 and DMAP (97 mg, 0.8 mmol) was added dropwise a solution of propane-1-sulfonyl chloride (97 mg, 0.8 mmol) in CH2Cl2. The resulting mixture was stirred at room temperature over night, diluted with 50 ml of CH2Cl2, extracted subsequently with water, 1 M HCl, and brine, tried over Na2SO4, filtered and the solvent evaporated to obtain 197.5 mg of product which was used in the next step without further purification.

1. extractionextracted subsequently with water, 1 M HCl, and brine
2. filtrationfiltered
3. customthe solvent evaporated