N-{[7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide hydrochloride → Methanesulfonic acid 1-(propane-1-sulfonyl)-azetidin-3-ylmethyl ester

HRID 1044541Notes

Reaction equation

HRID 1044541 reaction equation
[CH2:1]([S:4]([N:7]1[CH2:10][CH:9]([CH2:11][OH:12])[CH2:8]1)(=[O:6])=[O:5])[CH2:2][CH3:3].Cl.NC1C(CC2C=CC(Cl)=C(Cl)C=2)C2C=C(CN[S:36]([CH2:39]CC)(=[O:38])=[O:37])C=CC=2CC1>>[CH2:1]([S:4]([N:7]1[CH2:8][CH:9]([CH2:11][O:12][S:36]([CH3:39])(=[O:38])=[O:37])[CH2:10]1)(=[O:6])=[O:5])[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 57467213N-{[7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}propane-1-sulfonamide hydrochlorideHCID 59547792[1-(Propane-1-sulfonyl)-azetidin-3-yl]methanol

Product 1

HCID 57476714Methanesulfonic acid 1-(propane-1-sulfonyl)-azetidin-3-ylmethyl ester

Procedure

Prepared by standard procedure from [1-(propane-1-sulfonyl)-azetidin-3-yl]methanol and methan-1-sulfonyl chloride (e.g. example 40)

Sources & evidence

ORD record
ord-505c03fc9eac4cd38f9ec6fcf0b52193
Source dataset
uspto-grants-2013_10
Patent number
US08563617B2

Reaction notes

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