反应详情

The synthesis method shall be explained concretely, and in order, below. 4,6-dimorpholino-2-(4-phenylpiperazin-1-yl)pyrimidine (380 mg, 0.926 mmol) was dissolved in dichloromethane (5 ml), and N-fluoro-2,4,6-trimethylpyridinium triflate (402 mg, 1.39 mmol) was added. After agitation for 30 minutes at room temperature, water was added and extraction was done with dichloromethane. After washing the organic layer with saturated saline, drying was done with MgSO4, and the solvent was distilled away under reduced pressure. Purification was done by silica gel chromatography (hexane:ethyl acetate=4:1), and 122 mg of 4,6-dimorpholino-5-fluoro-2-(4-phenylpiperazin-1-yl)pyrimidine was obtained (yield 31%). The melting point measurement result, the MS measurement result, and the NMR data for the obtained Compound 82 are shown below.

1. customThe synthesis method
2. extractionextraction
3. washAfter washing the organic layer with saturated saline
4. customdrying
5. distillationthe solvent was distilled away under reduced pressure
6. customPurification