Nitrogen → HCID 178511560, compound

HRID 1044813Notes

Reaction equation

HRID 1044813 reaction equation
N#N.C(OC([NH:13][C@H:14]1[CH2:19][CH2:18][C@H:17]([CH2:20][OH:21])[CH2:16][CH2:15]1)=O)C1C=CC=CC=1>CO.[Pd]>[NH2:13][C@H:14]1[CH2:19][CH2:18][C@H:17]([CH2:20][OH:21])[CH2:16][CH2:15]1

Participants

5

Reactant 2

HCID 947NitrogenHCID 178523769HCID 178523769, compound

Product 1

HCID 178511560HCID 178511560, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of trans-4-benzyloxycarbonylaminocyclohexane-methanol (110 mg, 0.42 mmol) in MeOH (5 mL) was hydrogenated in the presence of Pd/C (10%) at rt until completion of the reaction. The mixture was then filtered and concentrated under reduced pressure. The title compound was obtained as a light brown solid. LC-MS-conditions 07: tR=0.11 min; [M+H]+=130.24.

Workup

  1. filtrationThe mixture was then filtered
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-617d28bc19024c01abb581761c1cee1d
Source dataset
uspto-grants-2013_10
Patent number
US08563714B2

Reaction notes

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