Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1044856Generated: October 31, 2026

tert-Butyl 4-(2-bromoethyl)piperidine-1-carboxylate → 1,1-Dimethylethyl 4-{2-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylate

https://huagongshe.com/reaction/1044856

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl 4-(2-bromoethyl)piperidine-1-carboxylateHCID 10541625—
Reactant2-Butoxy-9-(1-tert-butoxycarbonylpiperidin-4-ylmethyl)-8-methoxyadenineHCID 58306091—
ReactantHCID 178450370HCID 178450370—
SolventChloroform methanolHCID 21584188—
Product1,1-Dimethylethyl 4-{2-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylateHCID 58306196—

Reaction Steps

Prepared similarly to Intermediate 13 from 2-butoxy-8-methoxy-9H-purin-6-amine trifluoroacetate salt and 1,1-dimethylethyl 4-(2-bromoethyl)-1-piperidinecarboxylate. TLC chloroform/methanol 9:1:Rf 0.81

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08563717B2
Source datasetuspto-grants-2013_10
ORD IDord-86d3b701999f427d892a51e998a4ebbb
Source noteuspto-grants-2013_10