HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodoethane → 9-[2-(1-Ethyl-3-piperidinyl)ethyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[2-(3-piperidinyl)ethyl]-9H-purin-6-amine | HCID 58306084 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 9-[2-(1-Ethyl-3-piperidinyl)ethyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine | HCID 58306212 | — |
Reaction Steps
A solution of 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9-[2-(3-piperidinyl)ethyl]-9H-purin-6-amine (45 mg, 0.124 mmol), iodoethane (0.012 ml, 0.149 mmol) and triethylamine (0.035 mL, 0.248 mmol) in DMF (3 ml) was heated at 50° C. for 18 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563717B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-d1a94b0b2f5f48a59f49d08d95aac98d |
| Source note | uspto-grants-2013_10 |