Iodoethane → 9-[2-(1-Ethyl-3-piperidinyl)ethyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine

HRID 1044880Notes

Reaction equation

HRID 1044880 reaction equation
[CH3:1][C@H:2]([O:6][C:7]1[N:15]=[C:14]2[C:10]([N:11]=[C:12]([O:24][CH3:25])[N:13]2[CH2:16][CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][NH:20][CH2:19]2)=[C:9]([NH2:26])[N:8]=1)[CH2:3][CH2:4][CH3:5].I[CH2:28][CH3:29].C(N(CC)CC)C>CN(C=O)C>[CH2:28]([N:20]1[CH2:21][CH2:22][CH2:23][CH:18]([CH2:17][CH2:16][N:13]2[C:12]([O:24][CH3:25])=[N:11][C:10]3[C:14]2=[N:15][C:7]([O:6][C@@H:2]([CH3:1])[CH2:3][CH2:4][CH3:5])=[N:8][C:9]=3[NH2:26])[CH2:19]1)[CH3:29]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 8471TriethylamineHCID 583060842-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[2-(3-piperidinyl)ethyl]-9H-purin-6-amine

Product 1

HCID 583062129-[2-(1-Ethyl-3-piperidinyl)ethyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9-[2-(3-piperidinyl)ethyl]-9H-purin-6-amine (45 mg, 0.124 mmol), iodoethane (0.012 ml, 0.149 mmol) and triethylamine (0.035 mL, 0.248 mmol) in DMF (3 ml) was heated at 50° C. for 18 hours.

Sources & evidence

ORD record
ord-d1a94b0b2f5f48a59f49d08d95aac98d
Source dataset
uspto-grants-2013_10
Patent number
US08563717B2

Reaction notes

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