Iodoethane → 9-[4-(1-Ethyl-3-piperidinyl)butyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine
Reaction equation
[CH2:1](N1CCCC(CCN2C(OC)=NC3C2=NC(O[C@@H](C)CCC)=NC=3N)C1)[CH3:2].[CH3:29][C@H:30]([O:34][C:35]1[N:43]=[C:42]2[C:38]([N:39]=[C:40]([O:54][CH3:55])[N:41]2[CH2:44][CH2:45][CH2:46][CH2:47][CH:48]2[CH2:53][CH2:52][CH2:51][NH:50][CH2:49]2)=[C:37]([NH2:56])[N:36]=1)[CH2:31][CH2:32][CH3:33].ICC>>[CH2:1]([N:50]1[CH2:51][CH2:52][CH2:53][CH:48]([CH2:47][CH2:46][CH2:45][CH2:44][N:41]2[C:40]([O:54][CH3:55])=[N:39][C:38]3[C:42]2=[N:43][C:35]([O:34][C@@H:30]([CH3:29])[CH2:31][CH2:32][CH3:33])=[N:36][C:37]=3[NH2:56])[CH2:49]1)[CH3:2]Participants
4
Reactant 3
Product 1
Procedure
Prepared similarly to Intermediate 46 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9-[4-(3-piperidinyl)butyl]-9H-purin-6-amine and 2-iodoethane.
Sources & evidence
- ORD record
- ord-650b3ea15528499e95e3584992d0ba37
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08563717B2
Reaction notes
Loading…