Iodoethane → 9-[2-(1-Ethyl-4-piperidinyl)ethyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine

HRID 1044913Notes

Reaction equation

HRID 1044913 reaction equation
[CH2:1](N1CCCC(CCN2C(OC)=NC3C2=NC(O[C@@H](C)CCC)=NC=3N)C1)[CH3:2].[CH3:29][C@H:30]([O:34][C:35]1[N:43]=[C:42]2[C:38]([N:39]=[C:40]([O:52][CH3:53])[N:41]2[CH2:44][CH2:45][CH:46]2[CH2:51][CH2:50][NH:49][CH2:48][CH2:47]2)=[C:37]([NH2:54])[N:36]=1)[CH2:31][CH2:32][CH3:33].ICC>>[CH2:1]([N:49]1[CH2:48][CH2:47][CH:46]([CH2:45][CH2:44][N:41]2[C:40]([O:52][CH3:53])=[N:39][C:38]3[C:42]2=[N:43][C:35]([O:34][C@@H:30]([CH3:29])[CH2:31][CH2:32][CH3:33])=[N:36][C:37]=3[NH2:54])[CH2:51][CH2:50]1)[CH3:2]

Participants

4

Reactant 3

HCID 6340IodoethaneHCID 583062129-[2-(1-Ethyl-3-piperidinyl)ethyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amineHCID 583062322-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[2-(4-piperidinyl)ethyl]-9H-purin-6-amine

Product 1

HCID 583062269-[2-(1-Ethyl-4-piperidinyl)ethyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine

Procedure

Prepared similarly to Intermediate 46 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9-[2-(4-piperidinyl)ethyl]-9H-purin-6-amine and 2-iodoethane. LCMS (System B): tRET=1.28 min; MH+ 391

Workup

  1. custom=1.28 min

Sources & evidence

ORD record
ord-ed70faf948d34659834665188017101c
Source dataset
uspto-grants-2013_10
Patent number
US08563717B2

Reaction notes

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