Hydrochloric Acid → HCID 67182317, compound

HRID 1044947Notes

Reaction equation

HRID 1044947 reaction equation
[CH2:1]([NH:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:24]C)[N:12]2[CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][N:18]([CH2:22][CH3:23])[CH2:17]2)=[C:8]([NH2:26])[N:7]=1)[CH2:2][CH2:3][CH3:4].Cl>CO.O1CCOCC1>[NH2:26][C:8]1[N:7]=[C:6]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:24])[N:12]2[CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][N:18]([CH2:22][CH3:23])[CH2:17]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58306204HCID 58306204, compound

Product 1

HCID 67182317HCID 67182317, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

N2-Butyl-9-[(1-ethyl-3-piperidinyl)methyl]-8-methoxy-9H-purine-2,6-diamine (120 mg) was dissolved in methanol (2 ml) and 4N hydrogen chloride in dioxan (1 ml) added. After 5 hours the reaction mixture was stripped, quenched with water then made basic with 1M aq potassium carbonate. The resulting solid was filtered, washed and dried to give the title compound as a crystalline solid, yield 86 mg.

Workup

  1. customquenched with water
  2. filtrationThe resulting solid was filtered
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-720ce37d5dcb4e7f898d14950288ae32
Source dataset
uspto-grants-2013_10
Patent number
US08563717B2

Reaction notes

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