反应详情

温度

25 °C

7-Fluoro-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one (270.5 g) was dissolved in water (2000 g) and admixed with sodium bisulfite (300 g). The mixture was heated to reflux, in the course of which it was vigorously stirred. After 2.25 h, the mixture was cooled to 25° C. and isolated by filtration on a suction filter. It was washed twice with water (500 g each time) and then dried under reduced pressure (<50 mbar, 50° C.). This gave 7-fluoro-1,3-dihydro-2H-indol-2-one as a white solid (206.3 g, 95.1% by weight, 95% yield).

1. temperatureThe mixture was heated
2. temperatureto reflux, in the course of which it
3. customisolated by filtration on a suction
4. filtrationfilter
5. washIt was washed twice with water (500 g each time)
6. customdried under reduced pressure (<50 mbar, 50° C.)