2-Indancarboxylic Acid → HCID 12691896, compound

HRID 1045060Notes

Reaction equation

HRID 1045060 reaction equation
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[C:10]([OH:12])=[O:11]>O=[Pt]=O.C(O)(=O)C>[CH2:1]1[CH:9]2[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[CH2:3][CH:2]1[C:10]([OH:12])=[O:11]

Participants

4

Reactant 1

HCID 5757772-Indancarboxylic Acid

Product 1

HCID 12691896HCID 12691896, compoundYield 97.1%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 176Acetic AcidSolvent

Procedure

An acetic acid solution of indan-2-carboxylic acid (500 mg, 3.0 mmol) was stirred under hydrogen pressure (40 psi) in the presence of a small amount of PtO2 in a sealed glass pressure vessel equipped with a manometer and pressure valve following a method analogous to General Procedure M to produce octahydro-indene-2-carboxylic acid (490 mg, 95% yield) as a mixture of isomers.

Workup

  1. customequipped with a manometer and pressure valve

Sources & evidence

ORD record
ord-94826dd62bad4a2f8d5d0892d3bc9f76
Source dataset
uspto-grants-2013_10
Patent number
US08563742B2

Reaction notes

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