反应详情

温度

50 °C

To a solution of 5-chloro-2-nitroaniline (25 g, 145 mmol) in AcOH (250 mL) was added N-iodosuccinimide (32.6 g 145 mmol). The mixture was stirred overnight at 50° C., cooled to rt and filtered. The solid residue was washed with AcOH, water, saturated aqueous NaHCO3 and water, and then dried to afford the desired product as a brown solid, which was used in the next step without further purification.

1. temperaturecooled to rt
2. filtrationfiltered
3. washThe solid residue was washed with AcOH, water, saturated aqueous NaHCO3 and water
4. customdried