HCID 67339782, compound → HCID 45375932, compound

HRID 1045100Notes

Reaction equation

HRID 1045100 reaction equation
[Cl:1][C:2]1[C:3]([C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[OH:32])=[CH:22][CH:21]=2)=[CH:4][C:5]2[N:9]=[C:8]([S:10][CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])[NH:7][C:6]=2[CH:19]=1>C(O)(C(F)(F)F)=O.O>[Cl:1][C:2]1[C:3]([C:20]2[CH:21]=[CH:22][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[OH:32])=[CH:24][CH:25]=2)=[CH:4][C:5]2[N:9]=[C:8]([S:10][CH2:11][C:12]([OH:14])=[O:13])[NH:7][C:6]=2[CH:19]=1

Participants

4

Reactant 1

HCID 67339782HCID 67339782, compound

Product 1

HCID 45375932HCID 45375932, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl 2-(6-chloro-5-(2′-hydroxybiphenyl-4-yl)-1H-benzo[d]imidazol-2-ylthio)acetate in TFA (0.9 mL) and water (0.1 mL) was stirred at room temperature for 2 h and concentrated. The resultant solid was purified with HPLC to afford the desired product. LCMS: calculated for C21H15ClN2O3S 410.05, observed m/e 411.0 (M+H)+.

Workup

  1. concentrationconcentrated
  2. customThe resultant solid was purified with HPLC

Sources & evidence

ORD record
ord-8e168fec6ab14499b0e19ff51b81809c
Source dataset
uspto-grants-2013_10
Patent number
US08563746B2

Reaction notes

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