HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 10220296, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 2-Bromonaphthalene | HCID 11372 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Reactant | HCID 178418255 | HCID 178418255 | — |
| Reactant | HCID 178418423 | HCID 178418423 | — |
| Product | HCID 10220296 | HCID 10220296 | — |
Reaction Steps
An operation was carried out in the same manner as in Example 14, except that 0.63 mL (0.375 mmol) of 2-naphthylmagnesium bromide (0.60 mol/L) prepared from magnesium and 2-bromonaphthalene was used instead of the anhydrous THF solution of phenylmagnesium bromide. Thus, (S)-1-naphthylphenylmethanol was obtained. The conversion rate of the raw material was 99%, while the enantiomeric excess was 80% ee.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563786B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-628445e991cc429aa4e4664b8dedbe58 |
| Source note | uspto-grants-2013_10 |