Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1,4-Dioxa-8-azaspiro(4.5)decane | HCID 67435 | — |
| Reactant | Benzoic acid, 4-fluoro-2-phenoxy-, methyl ester | HCID 67144536 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67226454 | HCID 67226454 | — |
Reaction Steps
Methyl 4-fluoro-2-phenoxybenzoate (2 g) and 1,4-dioxa-8-azaspiro[4.5]decane (1.279 g) were combined in dimethylsulfoxideO (12 mL) in a 250 mL round-bottom flask. Sodium carbonate (1.291 g) was added. The reaction flask was sealed and heated to 130° C. overnight. The reaction mixture was diluted with ethyl acetate, washed thoroughly with water and with brine, and dried over MgSO4, filtered and concentrated to obtain the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08563735B2 |
|---|
| Source dataset | uspto-grants-2013_10 |
|---|
| ORD ID | ord-cfa3c6f649fb48c3a76e2540f968f687 |
|---|
| Source note | uspto-grants-2013_10 |
|---|
