HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Acetate → [4-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl]boronic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | Sodium periodate | HCID 23667635 | — |
| Reactant | 5-Methyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1,2,4-oxadiazole | HCID 59232390 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | [4-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl]boronic acid | HCID 22277087 | — |
Reaction Steps
A suspension of the product obtained in Step D above (6.5 g, 22.7 mmol) in 230 ml of acetone is stirred for 24 hours in the presence of 18.4 g (86.0 mmol) of sodium meta-periodate and 70 ml of aqueous 1M ammonium acetate solution. The acetone is evaporated off using a rotary evaporator and, after adding water, the reaction mixture is extracted with ethyl acetate. The organic phases are combined, washed (NaCl) and dried (MgSO4) to yield, after evaporation, the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569285B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-d7c0e318d44b4eaca00679fea41bfb3d |
| Source note | uspto-grants-2013_10 |