2,5-Dichloro-nicotinoyl chloride → HCID 86668354, compound

HRID 1045491Notes

Reaction equation

HRID 1045491 reaction equation
[NH2:1][C:2]1[CH:28]=[CH:27][C:5]([O:6][C:7]2[C:16]3[CH2:15][N:14]([CH2:17][C:18]4[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=4)[C:13](=[O:26])[NH:12][C:11]=3[N:10]=[CH:9][CH:8]=2)=[C:4]([F:29])[CH:3]=1.[Cl:30][C:31]1[C:36]([C:37](Cl)=[O:38])=[CH:35][C:34]([Cl:40])=[CH:33][N:32]=1>N1C=CC=CC=1>[Cl:30][C:31]1[N:32]=[CH:33][C:34]([Cl:40])=[CH:35][C:36]=1[C:37]([NH:1][C:2]1[CH:28]=[CH:27][C:5]([O:6][C:7]2[C:16]3[CH2:15][N:14]([CH2:17][C:18]4[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=4)[C:13](=[O:26])[NH:12][C:11]=3[N:10]=[CH:9][CH:8]=2)=[C:4]([F:29])[CH:3]=1)=[O:38]

Participants

4

Reactant 2

HCID 27999962,5-Dichloro-nicotinoyl chlorideHCID 70498061HCID 70498061, compound

Product 1

HCID 86668354HCID 86668354, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

57 (50 mg, 0.13 mmol) and 2,5-dichloropyridine-3-carbonyl chloride (29 mg, 0.14 mmol) were suspended in pyridine (1 mL), and stirred overnight at room temperature. The crude product was purified directly via HPLC. LC-MS (M+H=568, obsd.=568).

Workup

  1. customThe crude product was purified directly via HPLC

Sources & evidence

ORD record
ord-ab13771656b241d4b19d0e700c0b933b
Source dataset
uspto-grants-2013_10
Patent number
US08569295B2

Reaction notes

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