2-Fluorobenzenesulphonyl chloride → HCID 70498545, compound

HRID 1045492Notes

Reaction equation

HRID 1045492 reaction equation
[NH2:1][C:2]1[CH:28]=[CH:27][C:5]([O:6][C:7]2[C:16]3[CH2:15][N:14]([CH2:17][C:18]4[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=4)[C:13](=[O:26])[NH:12][C:11]=3[N:10]=[CH:9][CH:8]=2)=[C:4]([F:29])[CH:3]=1.[F:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[S:37](Cl)(=[O:39])=[O:38]>N1C=CC=CC=1>[F:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[S:37]([NH:1][C:2]1[CH:28]=[CH:27][C:5]([O:6][C:7]2[C:16]3[CH2:15][N:14]([CH2:17][C:18]4[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=4)[C:13](=[O:26])[NH:12][C:11]=3[N:10]=[CH:9][CH:8]=2)=[C:4]([F:29])[CH:3]=1)(=[O:39])=[O:38]

Participants

4

Reactant 2

HCID 1377612-Fluorobenzenesulphonyl chlorideHCID 70498061HCID 70498061, compound

Product 1

HCID 70498545HCID 70498545, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

57 (45 mg, 0.11 mmol) and 2-fluorobenzenesulfonyl chloride (24 mg, 0.12 mmol) were suspended in pyridine (1 mL), and stirred overnight at room temperature. The crude product was purified directly via HPLC. LC-MS (M+H=553, obsd.=553).

Workup

  1. customThe crude product was purified directly via HPLC

Sources & evidence

ORD record
ord-14688beb4f544a3cbfc9da02a3a66198
Source dataset
uspto-grants-2013_10
Patent number
US08569295B2

Reaction notes

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