4-Fluoro-1-isocyanato-2-(trifluoromethyl)benzene → N-[4-fluoro-2-(trifluoromethyl)phenyl]-N'-(4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]amino}phenyl)urea

HRID 1045499Notes

Reaction equation

HRID 1045499 reaction equation
[NH2:1][C:2](=C)/[CH:3]=[CH:4]/[C:5](/[NH:8][C:9]1[C:18]2[CH2:17][N:16]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[C:15](=[O:28])[NH:14][C:13]=2[N:12]=[CH:11][CH:10]=1)=[CH:6]/[CH3:7].[F:30][C:31]1[CH:36]=[CH:35][C:34]([N:37]=[C:38]=[O:39])=[C:33]([C:40]([F:43])([F:42])[F:41])[CH:32]=1>>[F:30][C:31]1[CH:36]=[CH:35][C:34]([NH:37][C:38]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([NH:8][C:9]3[C:18]4[CH2:17][N:16]([CH2:19][C:20]5[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=5)[C:15](=[O:28])[NH:14][C:13]=4[N:12]=[CH:11][CH:10]=3)=[CH:4][CH:3]=2)=[O:39])=[C:33]([C:40]([F:41])([F:42])[F:43])[CH:32]=1

Participants

3

Reactant 2

HCID 27333824-Fluoro-1-isocyanato-2-(trifluoromethyl)benzeneHCID 1317309205-[(Z)-4-amino-1-eth-(E)-ylidene-penta-2,4-dienylamino]-3-(4-methoxy-benzyl)-3,4-dihydro-1 H-pyrido[2,3-d]pyrimidin-2-one

Product 1

HCID 70498022N-[4-fluoro-2-(trifluoromethyl)phenyl]-N'-(4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]amino}phenyl)urea

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 63 using 5-[(Z)-4-amino-1-eth-(E)-ylidene-penta-2,4-dienylamino]-3-(4-methoxy-benzyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidin-2-one and 4-fluoro-1-isocyanato-2-trifluoromethyl-benzene. LC-MS (M+H=581, obsd.=581).

Sources & evidence

ORD record
ord-2649bd06c94444e880f441197106ed29
Source dataset
uspto-grants-2013_10
Patent number
US08569295B2

Reaction notes

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