4-Fluoro-1-isocyanato-2-(trifluoromethyl)benzene → N-[4-fluoro-2-(trifluoromethyl)phenyl]-N'-(4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]amino}phenyl)urea

Participants

Role	Name	HCID	Charge
Reactant	4-Fluoro-1-isocyanato-2-(trifluoromethyl)benzene	HCID 2733382	—
Reactant	5-[(Z)-4-amino-1-eth-(E)-ylidene-penta-2,4-dienylamino]-3-(4-methoxy-benzyl)-3,4-dihydro-1 H-pyrido[2,3-d]pyrimidin-2-one	HCID 131730920	—
Product	N-[4-fluoro-2-(trifluoromethyl)phenyl]-N'-(4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]amino}phenyl)urea	HCID 70498022	—

Reaction Steps

The title compound was synthesized according to the procedure described for the preparation of Example 63 using 5-[(Z)-4-amino-1-eth-(E)-ylidene-penta-2,4-dienylamino]-3-(4-methoxy-benzyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidin-2-one and 4-fluoro-1-isocyanato-2-trifluoromethyl-benzene. LC-MS (M+H=581, obsd.=581).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08569295B2
Source dataset	uspto-grants-2013_10
ORD ID	ord-2649bd06c94444e880f441197106ed29
Source note	uspto-grants-2013_10