HRID1045501

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2736913

3,4-Difluorobenzenesulfonyl chloride

C6H3ClF2O2S

结构：C=C(N)/C=C/C(=C/C)Nc1ccnc2c1CN(Cc1ccc(OC)cc1)C(=O)N2

HCID131730920

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CN2Cc3c(Nc4ccc(NS(=O)(=O)c5ccc(F)c(F)c5)cc4)ccnc3NC2=O)cc1

HCID70497527

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized according to the procedure described for the preparation of Example 62 using 5-[(Z)-4-amino-1-eth-(E)-ylidene-penta-2,4-dienylamino]-3-(4-methoxy-benzyl)-3,4-dihydro-1 H-pyrido[2,3-d]pyrimidin-2-one and 3,4-difluoro-benzenesulfonyl chloride. LC-MS (M+H=552, obsd.=552).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ffe7b3e416a34e659bbb0c708b3cf3f1
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08569295B2
来源说明: uspto-grants-2013_10

反应 SMILES

[NH2:1][C:2](=C)/[CH:3]=[CH:4]/[C:5](/[NH:8][C:9]1[C:18]2[CH2:17][N:16]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[C:15](=[O:28])[NH:14][C:13]=2[N:12]=[CH:11][CH:10]=1)=[CH:6]/[CH3:7].[F:30][C:31]1[CH:32]=[C:33]([S:38](Cl)(=[O:40])=[O:39])[CH:34]=[CH:35][C:36]=1[F:37]>>[F:30][C:31]1[CH:32]=[C:33]([S:38]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([NH:8][C:9]3[C:18]4[CH2:17][N:16]([CH2:19][C:20]5[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=5)[C:15](=[O:28])[NH:14][C:13]=4[N:12]=[CH:11][CH:10]=3)=[CH:4][CH:3]=2)(=[O:40])=[O:39])[CH:34]=[CH:35][C:36]=1[F:37]