HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Difluorobenzene-1-sulfonyl chloride → 3,4-difluoro-N-(4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]amino}phenyl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Difluorobenzene-1-sulfonyl chloride | HCID 2736913 | — |
| Reactant | 5-[(Z)-4-amino-1-eth-(E)-ylidene-penta-2,4-dienylamino]-3-(4-methoxy-benzyl)-3,4-dihydro-1 H-pyrido[2,3-d]pyrimidin-2-one | HCID 131730920 | — |
| Product | 3,4-difluoro-N-(4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]amino}phenyl)benzenesulfonamide | HCID 70497527 | — |
Reaction Steps
The title compound was synthesized according to the procedure described for the preparation of Example 62 using 5-[(Z)-4-amino-1-eth-(E)-ylidene-penta-2,4-dienylamino]-3-(4-methoxy-benzyl)-3,4-dihydro-1 H-pyrido[2,3-d]pyrimidin-2-one and 3,4-difluoro-benzenesulfonyl chloride. LC-MS (M+H=552, obsd.=552).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569295B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-ffe7b3e416a34e659bbb0c708b3cf3f1 |
| Source note | uspto-grants-2013_10 |