反应详情

温度

80 °C

A solution of compound 278 (22.00 mg; 0.03 mmol; 1.00 eq.) and trifluoroacetic acid (2.00 ml) was stirred at 80 degrees C. overnight. The reaction was stirred at 80 degrees C. for 22 hr. The reaction was concentrated, redissolved in DMSO, and treated with Et3N to pH 8. The solution was then purified directly via prep HPLC to afford 13 mg (60%) of 279 as a yellow solid. LC-MS (M+H=526, obsd.=526).

1. customovernight
2. concentrationThe reaction was concentrated
3. dissolutionredissolved in DMSO
4. additiontreated with Et3N to pH 8
5. customThe solution was then purified directly via prep HPLC