HCID 58432809, compound → HCID 58432794, compound

HRID 1045514Notes

Reaction equation

HRID 1045514 reaction equation
C(OC(=O)[NH:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[CH2:16][C:15]1([C:23](=[O:24])[NH:22][C:21]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[N:20]1)[CH2:14]2)C1C=CC=CC=1>CO.[Pd]>[NH2:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[CH2:16][C:15]1([C:23](=[O:24])[NH:22][C:21]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)=[N:20]1)[CH2:14]2

Participants

4

Reactant 1

HCID 58432809HCID 58432809, compound

Product 1

HCID 58432794HCID 58432794, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of (±)-benzyl (5-oxo-2-phenyl-1,1′,3′,5-tetrahydrospiro[imidazole-4,2′-inden]-5′-yl)carbamate from Step A (568 mg, 1.94 mmol) in degassed MeOH (2 mL) was added 10% palladium on carbon (5 mg). The suspension was placed under a hydrogen balloon for 3 h, then filtered through a pad of Celite, concentrated, and dried under high vacuum to give the title compound. MS: m/z=278 (M+1).

Workup

  1. customfor 3 h
  2. filtrationfiltered through a pad of Celite
  3. concentrationconcentrated
  4. customdried under high vacuum

Sources & evidence

ORD record
ord-89f37d6747a84808af0520b569105d7a
Source dataset
uspto-grants-2013_10
Patent number
US08569291B2

Reaction notes

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