HCID 67389382, compound → HCID 58432798, compound

HRID 1045520Notes

Reaction equation

HRID 1045520 reaction equation
[C:1]([C:5]1[NH:6][C:7](=[O:21])[C:8]2([N:20]=1)[CH2:16][C:15]1[C:10](=[CH:11][CH:12]=[C:13]([N+:17]([O-])=O)[CH:14]=1)[CH2:9]2)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[NH2:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[CH2:9][C:8]1([C:7](=[O:21])[NH:6][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[N:20]1)[CH2:16]2

Participants

4

Reactant 1

HCID 67389382HCID 67389382, compound

Product 1

HCID 58432798HCID 58432798, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of (±)-2-tert-butyl-5′-nitro-1′,3′-dihydrospiro[imidazole-4,2′-inden]-5(1H)-one from Step B (22.0 mg, 0.077 mmol) in degassed MeOH (5 mL) was added 10% palladium on carbon (10 mg). The suspension was placed under a hydrogen balloon for 1 h, then filtered through a pad of Celite, concentrated, and dried under high vacuum to give the title compound. MS: m/z=258 (M+1).

Workup

  1. customfor 1 h
  2. filtrationfiltered through a pad of Celite
  3. concentrationconcentrated
  4. customdried under high vacuum

Sources & evidence

ORD record
ord-bdb257c34bc242418aeff05a77020ddb
Source dataset
uspto-grants-2013_10
Patent number
US08569291B2

Reaction notes

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