HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1045634Generated: November 2, 2026
Thiourea → 3-Carbamimidoylsulfanylmethyl-pyrazine-2-carboxylic acid ethyl ester hydrobromide
https://huagongshe.com/reaction/1045634
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 3-Bromomethyl-pyrazine-2-carboxylic acid ethyl ester | HCID 66788825 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Carbamimidoylsulfanylmethyl-pyrazine-2-carboxylic acid ethyl ester hydrobromide | HCID 66788977 | 84.1% |
Reaction Steps
A suspension of thiourea (620 mg) and 3-bromomethyl-pyrazine-2-carboxylic acid ethyl ester (2 g) in tetrahydrofuran was heated in the microwave at 120° C. for 5 minutes. The product formed an oil so the tetrahydrofuran was simply decanted to leave 3-carbamimidoylsulfanylmethyl-pyrazine-2-carboxylic acid ethyl ester hydrobromide (2.2 g) as an oil. MH+=241, RT=0.26 min (Method A).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08569301B2 |
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| Source dataset | uspto-grants-2013_10 |
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| ORD ID | ord-a71f81707b8d4698b12bb5f5ec676672 |
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| Source note | uspto-grants-2013_10 |
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